the effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of alzheimer’s disease

Authors

mina eftekharzadeh department of anatomy, faculty of medicine, iran university of medical sciences, tehran, iran

maliheh nobakht department of anatomy, faculty of medicine, iran university of medical sciences, tehran, iran

cellular and molecular research center, iran university of medical sciences, tehran, iran

akram alizadeh department of tissue engineering, school of advanced technologies in medicine, tehran university of medical sciences, tehran, iran

abstract

objective(s): intracerebral injection of bone marrow stromal cells (bmscs) is being investigated as a therapeutic tool to prevent alzheimer's disease (ad). our aim was to investigate the effects of bmscs by intrathecal injection in ad rat model. materials and methods: bmscs were obtained from the bone marrow of wistar rat and transplanted into ad rat model via intrathecal injection. the rat model had received an injection of β amyloid into the hippocampus for histological and immunohistochemical studies. results: histological examination of the brains in transplanted rats compared to controls demonstrated the migration of brdu-labeled bmscs from the site of delivery, confirmed the differentiation of bmscs transplanted cells into the cholinergic neurons, and increased number of healthy and decreased number of dark neurons. conclusion: our results showed that bmscs intratechal administration could be a promising method for treatment ofalzheimer’s disease in rat model.

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Journal title:
iranian journal of basic medical sciences

جلد ۱۸، شماره ۵، صفحات ۵۲۰-۵۲۵

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